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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Drug-based optical agents: Infiltrating clinics at lower risk.
Sci. Transl. Med. 4:134ps11 (2012)
Fluorescent agents with specificity to cellular and subcellular moieties present promise for enhancing diagnostics and theranostics, yet challenges associated with regulatory approvals of experimental agents stifle the clinical translation. As a result, targeted fluorescent agents have remained predominantly as preclinical imaging tools. We discuss the potential of using optically labeled drugs to accelerate the clinical acceptance of optical and optoacoustic agents, in analogy to nuclear medicine approaches. This strategy, corroborated with microdosing studies, outlines a promising approach for overcoming bottlenecks and advancing photonic clinical imaging.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
COLORECTAL-CANCER; IN-VIVO; PET; ONCOLOGY
ISSN (print) / ISBN
1946-6234
e-ISSN
1946-6242
Zeitschrift
Science Translational Medicine
Quellenangaben
Band: 4,
Heft: 134,
Artikelnummer: 134ps11
Verlag
American Association for the Advancement of Science (AAAS)
Begutachtungsstatus
Peer reviewed