Startseite
English
Erweiterte Suche
Durchblättern nach ...
Publikationen im Überblick
Ansprechpartner
Hilfe
DOI
PMC
 |
|
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Dynamics in multi-domain protein recognition of RNA.
Curr. Opin. Struct. Biol. 22, 287-296 (2012)
Protein-RNA interactions play essential roles in gene regulation and RNA metabolism. While high-resolution structures have revealed principles of RNA recognition by individual RNA binding domains (RBDs), the presence of multiple RBDs in many eukaryotic proteins suggests additional modes of RNA recognition by combination and cooperation of these interactions. Recent structures, together with biochemical and biophysical studies have revealed novel principles of RNA recognition by multi-domain proteins. These examples highlight an important role for dynamics in RNA recognition, with mechanisms including fly-casting and conformational selection, and advocate the use of solution techniques for their analysis.
Altmetric
Weitere Metriken?
Zusatzinfos bearbeiten
[➜Einloggen]
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
MAGNETIC-RESONANCE-SPECTROSCOPY; MOLECULAR-WEIGHT PROTEINS; EXPORT FACTOR TAP; X-RAY-SCATTERING; STRUCTURAL BASIS; NMR-SPECTROSCOPY; BINDING PROTEINS; COMPLEX REVEALS; CONFORMATIONAL SELECTION; SPLICING REGULATION
ISSN (print) / ISBN
0959-440X
e-ISSN
1879-033X
Zeitschrift
Current Opinion in Structural Biology
Quellenangaben
Band: 22,
Heft: 3,
Seiten: 287-296
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Structural Biology (STB)