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Fuchs, H. ; Neschen, S. ; Rozman, J. ; Rathkolb, B. ; Wagner, S. ; Adler, T. ; Alfonso, L. ; Aguilar-Pimentel, J.A.* ; Becker, L. ; Bohla, A. ; Calzada-Wack, J. ; Cohrs, C.M. ; Frankó, A. ; Garrett, L. ; Glasl, L. ; Götz, A. ; Hagn, M. ; Hans, W. ; Hölter, S.M. ; Horsch, M. ; Kahle-Stephan, M. ; Kistler, M. ; Klein-Rodewald, T. ; Lengger, C. ; Ludwig, T. ; Maier, H. ; Marschall, S. ; Micklich, K. ; Möller, G. ; Naton, B. ; Neff, F. ; Prehn, C. ; Puk, O. ; Rácz, I.* ; Räß, M. ; Scheerer, M. ; Schiller, E. ; Schöfer, F.H. ; Schrewe, A. ; Steinkamp, R. ; Stoeger, C. ; Treise, I. ; Willershäuser, M. ; Zimprich, A. ; Zeh, R.M. ; Adamski, J. ; Beckers, J. ; Bekeredjian, R.* ; Busch, D.H.* ; Favor, J. ; Graw, J. ; Katus, H.A.* ; Klopstock, T.* ; Ollert, M.* ; Schulz, H. ; Stöger, T.* ; Wurst, W. ; Yildirim, A.Ö. ; Zimmer, A.* ; Wolf, E.* ; Klingenspor, M.* ; Gailus-Durner, V. ; Hrabě de Angelis, M.

Mouse genetics and metabolic mouse phenotyping.

In: Genetics Meets Metabolomics: from Experiment to Systems Biology. Springer, 2012. 85-106
DOI
The mouse is widely considered as a toolbox for modeling human diseases: mice are easy to handle and breed, there exist inbred strains, and the mouse genome sequence is available. Mutant mouse lines can be generated by different technologies, and standardized phenotyping of these mutant mouse lines produces a huge amount of valuable data. Useful resources for the scientific community are archives of mutant lines and strains as well as databases delivering information about the mouse lines and their availability. The phenotypic characterization of mutant mouse lines is the bottleneck within the pipeline from the generation via phenotyping to archiving of mutant mouse lines. Mouse clinics generate large data sets by the standardized, comprehensive phenotypic characterization of mutant mouse lines. There is a portfolio of phenotyping protocols available for a broad spectrum of disease areas that is considered as an international standard. For the investigation of human diseases like diabetes, obesity or the metabolic syndrome, metabolic tests to analyze mutant mouse lines become increasingly important. In this respect, challenge experiments have become the major focus to induce disease phenotypes in mutant mice that would remain undiscovered without the environmental challenges. These experimental setups reflect human conditions, where genetic predisposition and the environmental factors originating from different life style act together and enhance each other.
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Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Herausgeber Suhre, K.*
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISBN 978-1461416883
Bandtitel Genetics Meets Metabolomics: from Experiment to Systems Biology
Quellenangaben Band: , Heft: , Seiten: 85-106 Artikelnummer: , Supplement: ,
Verlag Springer
Institut(e) Institute of Experimental Genetics (IEG)
Institute of Developmental Genetics (IDG)
Institute of Pathology (PATH)
Institute of Human Genetics (IHG)
Molekulare Endokrinologie und Metabolismus (MEM)
Institute of Lung Health and Immunity (LHI)
Institute of Epidemiology (EPI)
Institute for Allergy Research (IAF)
POF Topic(s) 30201 - Metabolic Health
30204 - Cell Programming and Repair
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30202 - Environmental Health
30503 - Chronic Diseases of the Lung and Allergies
80000 - German Center for Lung Research
90000 - German Center for Diabetes Research
Forschungsfeld(er) Genetics and Epidemiology
Enabling and Novel Technologies
Lung Research
Allergy
PSP-Element(e) G-500600-003
G-500500-001
G-500300-001
G-500700-002
G-500600-001
G-500600-004
G-505600-001
G-505000-007
G-500500-002
G-505000-001
G-503900-003
G-501800-541
G-501900-064
G-501900-066
G-501900-063
G-501900-062
G-500600-002
DOI 10.1007/978-1-4614-1689-0_7
Scopus ID 84929271938
Erfassungsdatum 2012-08-03
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