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Wendland, M.* ; Willenzon, S.* ; Kocks, J.* ; Davalos-Misslitz, A.C.* ; Hammerschmidt, S.I.* ; Schumann, K.* ; Kremmer, E. ; Sixt, M.* ; Hoffmeyer, A.* ; Pabst, O.* ; Forster, R.*

Lymph node T cell homeostasis relies on steady state homing of dendritic cells.

Immunity 35, 945-957 (2012)
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Little is known about mechanisms determining the homeostasis of lymphocytes within lymphoid organs. Applying different mouse models, including conditionally proficient Ccr7 gene-targeted mice, we now show that semimature steady state dendritic cells (sDCs) constitutively trafficking into lymph nodes (LNs) were essential contributors to T cell homeostasis in these organs. sDCs provided vascular endothelial growth factor known to support high endothelial venule formation, thus facilitating enhanced homing of T cells to LNs. The presence of sDCs led to increased CCL21 production in T-zone fibroblastic reticular cells. CCL21 is a ligand for CCR7 known to regulate homing as well as retention of T cells in LNs. In addition, we provide evidence that CCL21 binds to the surface of DCs via its heparin-binding domain, further explaining why T cells leave LNs more rapidly in the absence of sDCs. Together, these data reveal multiple roles for sDCs in regulating T cell homeostasis in LNs.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Migration; Ccr7; Organs; Sphingosine-1-Phosphate; Chemokines; Receptors; Tolerance; Motility; Egress; Entry
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 1074-7613
e-ISSN 1097-4180
Zeitschrift Immunity
Quellenangaben Band: 35, Heft: 6, Seiten: 945-957 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Molecular Immunology (IMI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Immune Response and Infection
PSP-Element(e) G-501793-001
PubMed ID 22195748
DOI 10.1016/j.immuni.2011.10.017
WOS ID WOS:000298777300013
Scopus ID 84255177550
Erfassungsdatum 2012-09-25
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