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Weigmann, B.* ; Daniel, C.

Treg vaccination with a strong-agonistic insulin mimetope.

Curr. Diab. Rep. 12, 463-470 (2012)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Foxp3(+) regulatory T (Treg) cells serve as a vital mechanism of negative regulation to maintain immunological self-tolerance thereby suppressing immune-mediated inflammation. The identification of the transcription factor Foxp3 as the specification factor for the Treg cell lineage facilitated our understanding in the biology of Treg generation and function. In the past, we carefully studied the extrathymic conversion of naive CD4(+) T cells into Foxp3(+) expressing Treg cells and found that this process is most efficient upon subimmunogenic supply of strong-agonistic T cell receptor (TCR) ligands avoiding activation of antigen-presenting and T cells. In contrast, weak-agonistic antigens fail to efficiently induce stable Foxp3(+) Treg cells irrespective of the applied dose. Here, we discuss the specific requirements for the establishment of Treg vaccination protocols to interfere with autoimmunity such as Type 1 diabetes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Autoimmunity ; Type 1 Diabetes ; Insulin Regulatory T Cells ; Foxp3 ; Mimetope ; Conversion ; Antigen ; Tolerance ; Treg Vaccination; REGULATORY T-CELLS; TYPE-1 DIABETES-MELLITUS; NOD MICE; IN-VIVO; FOXP3 EXPRESSION; IMMUNODOMINANT EPITOPE; STRUCTURAL BASIS; IMMUNE-RESPONSE; SELF-PEPTIDE; HUMAN THYMUS
Sprache englisch
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Zeitschrift Current Diabetes Reports
Quellenangaben Band: 12, Heft: 5, Seiten: 463-470 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes Research (IDF)
PSP-Element(e) G-552200-001
PubMed ID 22763731
DOI 10.1007/s11892-012-0295-2
WOS ID WOS:000308286400003
Erfassungsdatum 2012-09-27
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