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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Treg vaccination with a strong-agonistic insulin mimetope.
Curr. Diab. Rep. 12, 463-470 (2012)
Foxp3(+) regulatory T (Treg) cells serve as a vital mechanism of negative regulation to maintain immunological self-tolerance thereby suppressing immune-mediated inflammation. The identification of the transcription factor Foxp3 as the specification factor for the Treg cell lineage facilitated our understanding in the biology of Treg generation and function. In the past, we carefully studied the extrathymic conversion of naive CD4(+) T cells into Foxp3(+) expressing Treg cells and found that this process is most efficient upon subimmunogenic supply of strong-agonistic T cell receptor (TCR) ligands avoiding activation of antigen-presenting and T cells. In contrast, weak-agonistic antigens fail to efficiently induce stable Foxp3(+) Treg cells irrespective of the applied dose. Here, we discuss the specific requirements for the establishment of Treg vaccination protocols to interfere with autoimmunity such as Type 1 diabetes.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Autoimmunity ; Type 1 Diabetes ; Insulin Regulatory T Cells ; Foxp3 ; Mimetope ; Conversion ; Antigen ; Tolerance ; Treg Vaccination; REGULATORY T-CELLS; TYPE-1 DIABETES-MELLITUS; NOD MICE; IN-VIVO; FOXP3 EXPRESSION; IMMUNODOMINANT EPITOPE; STRUCTURAL BASIS; IMMUNE-RESPONSE; SELF-PEPTIDE; HUMAN THYMUS
ISSN (print) / ISBN
1534-4827
e-ISSN
1539-0829
Zeitschrift
Current Diabetes Reports
Quellenangaben
Band: 12,
Heft: 5,
Seiten: 463-470
Verlag
Springer
Verlagsort
Heidelberg [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Diabetes Research Type 1 (IDF)