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Raducanu, A. ; Lickert, H.

Understanding pancreas development for β-cell repair and replacement therapies.

Curr. Diab. Rep. 12, 481-489 (2012)
Postprint DOI PMC
Open Access Green
The lack or dysfunction of insulin-producing beta-cells is the cause of all forms of diabetes. In vitro generation of beta-cells from pluripotent stem cells for cell-replacement therapy or triggering endogenous mechanisms of beta-cell repair have great potential in the field of regenerative medicine. Both approaches rely on a thorough understanding of beta-cell development and homeostasis. Here, we briefly summarize the current knowledge of beta-cell differentiation during pancreas development in the mouse. Furthermore, we describe how this knowledge is translated to instruct differentiation of both mouse and human pluripotent stem cells towards the beta-cell lineage. Finally, we shortly summarize the current efforts to identify stem or progenitor cells in the adult pancreatic organ and to harness the endogenous regenerative potential. Understanding development and regeneration of beta-cells already led to identification of molecular targets for therapy and informed on pathomechanisms of diabetes. In the future might lead to beta-cell repair and replacement therapies.
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5
5
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter Development ; Regeneration ; Differentiation ; Pancreas ; Beta-cell ; Embryonic Stem Cells ; Progenitor Cells ; Signaling ; Transcription Factors ; Diabetes; Embryonic Stem-cells ; Vertebrate Endoderm Development ; Mouse Embryo ; Diabetes-mellitus ; Exocrine Pancreas ; Morphogenetic Function ; Transcription Factors ; Definitive Endoderm ; Endocrine Pancreas ; Progenitor Cells
Sprache
Veröffentlichungsjahr 2012
HGF-Berichtsjahr 2012
ISSN (print) / ISBN 1534-4827
e-ISSN 1539-0829
Zeitschrift Current Diabetes Reports
Quellenangaben Band: 12, Heft: 5, Seiten: 481-489 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Heidelberg [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Regeneration Research (IDR)
Institute of Stem Cell Research (ISF)
POF Topic(s) 90000 - German Center for Diabetes Research
30201 - Metabolic Health
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Helmholtz Diabetes Center
Stem Cell and Neuroscience
PSP-Element(e) G-501900-231
G-502300-001
G-500890-001
DOI 10.1007/s11892-012-0301-8
WOS ID WOS:000308286400005
Scopus ID 84870817674
PubMed ID 22782495
Erfassungsdatum 2012-09-27
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