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Schmid, O. ; Möller, W. ; Semmler-Behnke, M. ; Ferron, G.A. ; Karg, E.W. ; Lipka, J. ; Schulz, S. ; Kreyling, W.G. ; Stöger, T.

Dosimetry and toxicology of inhaled ultrafine particles.

Biomarkers 14, (Suppl.1), 67-73 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Both epidemiological and toxicological studies indicate that inhalation and subsequent deposition of air borne particles into the lungs have adverse health effects. Recently, the ultrafine particle (UfP) fraction (diameter < 100nm) has received particular attention, as their small size may lead to more toxic proper ties. In this study we summarize the current knowledge on the dosimetry of inhaled particles (including UfPs) with a focus on recent data on translocation of UfPs into secondary target organs (such as brain and heart) suggesting that the lifetime dose of ambient UfPs in secondary target organs is about 1011 particles. Furthermore, we highlight the main pathways of particle induced toxicity and the reasons for the potentially higher toxicity of UfPs. Finally, we discuss recent evidence indicating that (BET) surface area is the single most relevant dose metric for the toxicity of UfPs, which has important implications for regulatory measures on the toxicity of ambient and engineered particles.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Oxidative stress; lung; ROS; nanoparticle toxicity; BET surface area; particle toxicity; insoluble iridium particles; human respiratory-tract; in-vivo; oxidative stress; air-pollution; surface-area; utah valley; extrapulmonary translocation; particulate matter; organic-compounds
ISSN (print) / ISBN 1354-750X
e-ISSN 1366-5804
Zeitschrift Biomarkers
Quellenangaben Band: 14, Heft: SUPPL.1, Seiten: 67-73, Artikelnummer: , Supplement: (Suppl.1)
Verlag Informa Healthcare
Verlagsort Abingdon
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Lung Biology (LHI)
Lung Health and Immunity (LHI)
CCG Inflammatory Lung Diseases (CPC-KEL)
Cooperation Group Comprehensive Molecular Analytics (CMA)