PuSH - Publikationsserver des Helmholtz Zentrums München

Export: TXT Text RIS Endnote (RIS) BIB BibTeX
Simon-Sanchez, J.* ; Schulte, C.* ; Bras, J.M.* ; Sharma, M.* ; Gibbs, J.R.* ; Berg, D.* ; Paisan-Ruiz, C.* ; Lichtner, P. ; Scholz, S.W.* ; Hernandez, D.G.* ; Kruger, R.* ; Federoff, M.* ; Klein, C.* ; Goate, A.* ; Perlmutter, J.* ; Bonin, M.* ; Nalls, M.A.* ; Illig, T. ; Gieger, C. ; Houlden, H.* ; Steffens, M.* ; Okun, M.S.* ; Racette, B.A.* ; Cookson, M.R.* ; Foote, K.D.* ; Fernandez, H.H.* ; Traynor, B.J.* ; Schreiber, S.* ; Arepalli, S.* ; Zonozi, R.* ; Gwinn, K.* ; van der Brug, M.* ; Lopez, G.* ; Chanock, S.J.* ; Schatzkin, A.* ; Park, Y.* ; Hollenbeck, A.* ; Gao, J.J.* ; Huang, X.M.* ; Wood, N.W.* ; Lorenz, D.* ; Deuschl, G.* ; Chen, H.L.* ; Riess, O.* ; Hardy, J.A.* ; Singleton, A.B.* ; Gasser, T.*

Genome-wide association study reveals genetic risk underlying Parkinson's disease.

Nat. Genet. 41, 1308-1314 (2009)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
We performed a genome-wide association study (GWAS) in 1,713 individuals of European ancestry with Parkinson's disease (PD) and 3,978 controls. After replication in 3,361 cases and 4,573 controls, we observed two strong association signals, one in the gene encoding a-synuclein (SNCA; rs2736990, OR = 1.23, P = 2.24 x 10(-16)) and another at the MAPT locus (rs393152, OR = 0.77, P = 1.95 x 10(-16)). We exchanged data with colleagues performing a GWAS in Japanese PD cases. Association to PD at SNCA was replicated in the Japanese GWAS1, confirming this as a major risk locus across populations. We replicated the effect of a new locus detected in the Japanese cohort (PARK16, rs823128, OR = 0.66, P = 7.29 x 10(-8)) and provide supporting evidence that common variation around LRRK2 modulates risk for PD (rs1491923, OR = 1.14, P = 1.55 x 10(-5)). These data demonstrate an unequivocal role for common genetic variants in the etiology of typical PD and suggest population-specific genetic heterogeneity in this disease.
Impact Factor
Scopus SNIP
Web of Science
Times Cited
Scopus
Cited By
Altmetric
30.259
7.770
925
1445
Tags
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern

Zusatzinfos bearbeiten
Eigene Tags bearbeiten
Privat
Eigene Anmerkung bearbeiten
Privat
Auf Publikationslisten für
Homepage nicht anzeigen
Als besondere Publikation
markieren
Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter progressive supranuclear palsy; linkage disequilibrium; tau gene; haplotype; mutations; system; SNCA
Sprache
Veröffentlichungsjahr 2009
HGF-Berichtsjahr 2009
ISSN (print) / ISBN 1061-4036
e-ISSN 1546-1718
Zeitschrift Nature Genetics
Quellenangaben Band: 41, Heft: 12, Seiten: 1308-1314 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort New York, NY
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Human Genetics (IHG)
Institute of Epidemiology (EPI)
POF Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
Forschungsfeld(er) Genetics and Epidemiology
PSP-Element(e) G-500700-001
G-503900-001
G-500700-003
DOI 10.1038/ng.487
Scopus ID 70549088602
PubMed ID 19915575
Erfassungsdatum 2009-12-31
[➜Korrektur melden]