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Wong, P. ; Frishman, D.

Designability and Disease.

In:. Berlin [u.a.]: Springer, 2008. 491-504 (Methods Mol. Biol. ; 484)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Structural designability is the number of ways it is possible to encode for structure. A protein’s designability has been equated with the size of sequence space encoding for the protein’s structure, a measure that reflects the structure’s robustness to mutation. Current evidence suggests that designability is fundamental to our understanding of the evolvability and distribution of structures in nature and is a significant factor associated with human disease. Here, we describe definitions and principles underlying the concept of designability and discuss its relation to disease.
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Publikationstyp Artikel: Sammelbandbeitrag/Buchkapitel
Herausgeber Chen, E.H.*
Schlagwörter Protein evolution; structure classification; genome analysis; disease
ISSN (print) / ISBN 1064-3745
e-ISSN 1940-6029
ISBN 978-1-58829-971-0
Zeitschrift Methods in Molecular Biology
Quellenangaben Band: 484, Heft: , Seiten: 491-504 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort Berlin [u.a.]
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Bioinformatics and Systems Biology (IBIS)