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Kreuzer, M. ; Heinrich, J. ; Wölke, G. ; Schaffrath Rosario, A. ; Gerken, M.* ; Wellmann, J.* ; Keller, G.* ; Kreienbrock, L.* ; Wichmann, H.-E.

Residential Radon and Risk of Lung Cancer in Eastern Germany.

Epidemiology 14, 559-568 (2003)
DOI
Open Access Gold möglich sobald Verlagsversion bei der ZB eingereicht worden ist.
Background: There is suggestive evidence that residential radon increases lung cancer risk. To elucidate this association further, we conducted a case-control study in Thuringia and Saxony in Eastern Germany during 1990-1997. Methods: Histologically confirmed lung cancer patients from hospitals and a random sample of population controls matched on age, sex and geographical area were personally interviewed with respect to residential history, smoking, and other risk factors. One-year radon measurements were performed in houses occupied during the 5-35 years prior to the interview. The final analysis included a total of 1,192 cases and 1,640 controls. Odds ratios (OR) and 95% confidence intervals (CI) were estimated by logistic regression. Results: Measurements covered on average 72% of the exposure time window, with mean radon concentrations of 76 Bq/m3 among the cases and 74 Bq/m3 among the controls. The smoking- and asbestos-adjusted ORs for categories of radon (50-80, 80-140 and >140 Bq/m*3, compared with 0-50 Bq/m3) were 0.95 (CI = 0.77 to 1.18), 1.13 (CI = 0.86 to1.50) and 1.30 (CI = 0.88 to 1.93). The excess relative risk per 100 Bq/ml was 0.08 (CI = -0.03 to 0.20) for all subjects and 0.09 (CI = -0.06 to 0.27) for subjects with complete measurements for all 30 years. Conclusions: Our data indicate a small increase in lung cancer risk as a result of residential radon that is consistent with the findings of previous indoor radon and miner studies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter case-control-study; lung neoplasm; radon; tobacco smoke
ISSN (print) / ISBN 1044-3983
e-ISSN 1531-5487
Zeitschrift Epidemiology
Quellenangaben Band: 14, Heft: 5, Seiten: 559-568 Artikelnummer: , Supplement: ,
Verlag Lippincott Williams & Wilkins
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Epidemiology (EPI)