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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
From more to less than Haber's law.
Environ. Toxicol. Pharmacol. 11, 227-232 (2002)
We show how reformulating a first-order response theory with respect to both toxicant concentration and exposure time, in terms of relative instead of absolute increments, leads to a generalized version of Haber's law and to a combined sigmoid model for concentration and time response, derived on analytical rather than empirical grounds. More general presuppositions of Haber's law (without assuming sigmoid response) are briefly discussed. The relative intensities of time response and concentration response are measured by a single dimensionless parameter, characterizing each quadruple {toxicant, route, species, adverse effect}. Cross-species and cross-toxicant variability of this parameter is discussed and illustrated by new findings on algae and Daphniae exposed to selected inorganic and organic pollutants.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Time-dose additivity; Endpoint conversions; Haber's law; Pentachlorophenol; Daphnia magna; Scenedesmus subspicatus
ISSN (print) / ISBN
1382-6689
e-ISSN
1872-7077
Zeitschrift
Environmental Toxicology and Pharmacology
Quellenangaben
Band: 11,
Heft: 3-4,
Seiten: 227-232
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Ecological Chemistry (IOEC)
Institute of Groundwater Ecology (IGOE)
Institute of Molecular Toxicology and Pharmacology (TOXI)
Institute of Groundwater Ecology (IGOE)
Institute of Molecular Toxicology and Pharmacology (TOXI)