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Razansky, D. ; Vinegoni, C.* ; Ntziachristos, V.

Multi-spectral photo-acoustic molecular tomography resolves fluorochrome distribution with high resolution and sensitivity in small animals.

Proc. SPIE 6856:685613 (2008)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Current non-invasive imaging methods of fluorescent molecular probes in the visible and near-infrared suffer from low spatial resolution as a result of rapid light diffusion in biological tissues. We show that three-dimensional distribution of fluorochromes deep in small animals can be resolved with below 25 femtomole sensitivity and 150 microns spatial resolution by means of multi-spectral photo-acoustic molecular tomography. The low sensitivity limit of the method is enabled by using the highly resonant absorption spectrum of a commonly used near-infrared fluorescent molecular probe Alexa Fluor 750 in order to acquire differential images at multiple wavelengths with tomographic topology suitable for whole-body small animal imaging.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Herausgeber Oraevsky, A.A.* ; Wang, L.V.*
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Konferenztitel Photons Plus Ultrasound: Imaging and Sensing 2008: The Ninth Conference on Biomedical Thermoacoustics, Optoacoustics, and Acoust
Zeitschrift Proceedings of SPIE
Quellenangaben Band: 6856, Heft: , Seiten: , Artikelnummer: 685613 Supplement: ,
Reihe Proceedings of SPIE
Verlag SPIE
Verlagsort Bellingham, WA
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Biological and Medical Imaging (IBMI)