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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Increased Interleukin 4 (IL-4) Receptor Expression and IL-4-Induced Decrease in IL-12 Production by Langerhans Cells Infected with Leishmania major.
Infect. Immun. 70, 1627-1630 (2002)
Langerhans cells (LC) take up Leishmania major and are critical for the induction of the parasite-specific T-cell response. Their functional activities are regulated by cytokines. We analyzed whether infection of LC with L. major modulates the expression of their cytokine receptors. The expression of the interleukin 4 (IL-4) receptor was increased on infected LC from susceptible mice but not on those from resistant mice. Moreover, IL-4 treatment strongly decreased the lipopolysaccharide-induced IL-12 response of infected LC from susceptible mice. This modulation of IL-4 receptor expression and IL-12 production by infection of LC with Leishmania may contribute to the development of Th2 cells and to susceptibility to infection.
Impact Factor
Scopus SNIP
4.212
0.000
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
CD4(+) T-CELLS; DENDRITIC CELLS; CUTANEOUS LEISHMANIASIS; BALB/C MICE; MACROPHAGES; AMASTIGOTES; SUSCEPTIBILITY; PROMASTIGOTES; INITIATION; ACTIVATION
Sprache
englisch
Veröffentlichungsjahr
2002
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0019-9567
e-ISSN
1098-5522
Zeitschrift
Infection and Immunity
Quellenangaben
Band: 70,
Seiten: 1627-1630
Verlag
American Society for Microbiology (ASM)
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Tumor Therapy with Hyperthermia (IMI-KTH)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Immune Response and Infection
PSP-Element(e)
G-521100-001
Erfassungsdatum
2002-10-27