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Morgan, H.* ; Beck, T.* ; Blake, A.* ; Gates, H.* ; Adams, N.* ; Debouzy, G.* ; Leblanc, S.* ; Lengger, C. ; Maier, H. ; Melvin, D.* ; Meziane, H.* ; Richardson, D.* ; Wells, S.* ; White, J.* ; Wood, J.* ; EUMODIC Consortium (Hrabě de Angelis, M. ; Gailus-Durner, V. ; Fuchs, H. ; Adler, T. ; Aguilar-Pimentel, J.A. ; Becker, L. ; Beckeredjian, R ; Busch, D.H. ; Calzada-Wack, J. ; Da Silva-Buttkus, P. ; Esposito, I. ; Favor, J. ; Fleischmann, W. ; Garrett, L. ; Glasl, L. ; Götz, A. ; Graw, J. ; Hans, W, ; Hölter, S.M. ; Ivandic, B. ; Katus, H.A. ; Klingenspor, M. ; Klopstock, T. ; Lengger, C. ; Ludwig, T. ; Maier, H. ; Micklich, K. ; Minxuan, S. ; Naton, B. ; Neff, F. ; Ollert, M. ; Puk, O. ; Quintanilla-Fend, L. ; Rácz, I. ; Rathkolb, B. ; Rozman, J. ; Schäble, K.-H. ; Schiller, E. ; Schrewe, A. ; Steinkamp, R. ; Stoeger, C. ; Stöger, T. ; Schulz, S. ; Tost, M. ; Treise, I. ; Vogt Weisenhorn, D.M. ; Willershäuser, M. ; Wolf, E. ; Zimprich, A. ; Wurst, W. ; Zeh, R.M. ; Zimmer, A.) ; Hrabě de Angelis, M. ; Brown, S.* ; Hancock, J.M.* ; Mallon, A.M.*

EuroPhenome: A repository for high-throughput mouse phenotyping data.

Nucleic Acids Res. 38, 1, D577-D585 (2010)
Verlagsversion Volltext DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The broad aim of biomedical science in the postgenomic era is to link genomic and phenotype information to allow deeper understanding of the processes leading from genomic changes to altered phenotype and disease. The EuroPhenome project (http://www.EuroPhenome.org) is a comprehensive resource for raw and annotated high-throughput phenotyping data arising from projects such as EUMODIC. EUMODIC is gathering data from the EMPReSSslim pipeline (http://www.empress.har.mrc.ac.uk/) which is performed on inbred mouse strains and knock-out lines arising from the EUCOMM project. The EuroPhenome interface allows the user to access the data via the phenotype or genotype. It also allows the user to access the data in a variety of ways, including graphical display, statistical analysis and access to the raw data via web services. The raw phenotyping data captured in EuroPhenome is annotated by an annotation pipeline which automatically identifies statistically different mutants from the appropriate baseline and assigns ontology terms for that specific test. Mutant phenotypes can be quickly identified using two EuroPhenome tools: PhenoMap, a graphical representation of statistically relevant phenotypes, and mining for a mutant using ontology terms. To assist with data definition and cross-database comparisons, phenotype data is annotated using combinations of terms from biological ontologies.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Functional annotation; Empress; Ontologies; Resource; Screens; Animals; Computational Biology/methods; Computational Biology/trends; Databases; Genetic; Information Storage and Retrieval/methods; Internet; Mice; Inbred C57BL; Inbred Strains; Knockout; Phenotype; Software; FUNCTIONAL ANNOTATION; EMPRESS; ONTOLOGIES; RESOURCE; SCREENS
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Zeitschrift Nucleic Acids Research
Quellenangaben Band: 38, Heft: Database Issue, Seiten: D577-D585, Artikelnummer: , Supplement: 1
Verlag Oxford University Press
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Experimental Genetics (IEG)
Lung Health and Immunity (LHI)
Institute of Lung Biology (LHI)
Institute of Developmental Genetics (IDG)
Institute of Human Genetics (IHG)
CCG Antigen-specific Immunotherapy (VIRO-KVA)
Institute of Molecular Immunology (IMI)
Institute of Pathology (PATH)