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Heidenreich, W.F. ; Wellmann, J. ; Jacob, P. ; Wichmann, H.-E.

Mechanistic modelling in large case-control studies of lung cancer risk from smoking.

Stat. Med. 21, 3055-3070 (2002)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The two-step clonal expansion (TSCE) model is applied to large case-control studies, frequency matched for age, which allow estimation of the RR of lung tumour risk caused by smoking. For estimating background hazard rates, mortality data from the study areas are used to supplement the case-control data. Two approaches are used to analyse the data, based on the unconditional and the conditional likelihoods. They are demonstrated to give nearly identical results. Some model diagnostics are performed and demonstrate a good model fit. Our results indicate that smoking acts on the promotion and transformation parameters, but not on the initiation parameter of the TSCE model. The fitted relative risk of current smokers peaks between ages 50 and 60 years. The relative risk of male ex-smokers decreases strongly with time since end of exposure, but does not reach the risk of non-smokers, and does not decrease as much as for female ex-smokers.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter mechanistic models; two-step clonal expansion model; frequency matched case-control study; smoking; unconditional likelihood; conditional likelihood
Sprache englisch
Veröffentlichungsjahr 2002
HGF-Berichtsjahr 0
ISSN (print) / ISBN 0277-6715
e-ISSN 1097-0258
Zeitschrift Statistics in Medicine
Quellenangaben Band: 21, Heft: , Seiten: 3055-3070 Artikelnummer: , Supplement: ,
Verlag Wiley
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)
Institute of Epidemiology (EPI)
POF Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er) Radiation Sciences
PSP-Element(e) G-501100-004
G-503900-002
Erfassungsdatum 2002-10-24
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