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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on serum inhibin concentrations and inhibin immunostaining during follicular development in female Spraque-Dawley rats.
Reprod. Toxicol. 16, 97-105 (2002)
Intact and hypophysectomized immature rats were pretreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD; 0 or 32 mug/kg p.o.) and sacrificed throughout synchronized follicular development (0, 12, 24, 48, and 72 It after equine chorionic gonadotropin, eCG). TCDD administration to intact rats resulted in a premature elevation of serum FSH and LH by 12 h post-eCG. In intact rats pretreated with TCDD, the intensity of ovarian immunoreactivity for inhibin and the number of ovarian follicles staining for inhibin in midsaggital ovarian sections were decreased at the time of eCG administration (24 It post-TCDD) in comparison to controls. However, this decreased ovarian staining for inhibin was not associated with alterations in serum inhibin concentrations. Serum inhibin was suppressed in TCDD-treated rats when compared to intact controls only at 24 h post-eCG. Hypophysectomized animals exhibited no effect of TCDD on serum inhibin at any timepoint but did have decreased estradiol concentrations during follicular development. In summary, TCDD reduced serum concentrations of inhibin after the premature increases in FSH and LH suggesting that inhibin is not important in the initial elevation of FSH following exposure to TCDD.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
GONADOTROPIN-PRIMED RAT; IN-UTERO; LACTATIONAL EXPOSURE; OVULATION MODEL; CYCLIC HAMSTER; ESTROUS-CYCLE; HOLTZMAN RATS; STEROIDOGENESIS; MODULATION; ESTRADIOL
ISSN (print) / ISBN
0890-6238
e-ISSN
0890-6238
Zeitschrift
Reproductive Toxicology
Quellenangaben
Band: 16,
Seiten: 97-105
Verlag
Elsevier
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed