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Prokic, J. ; Jacob, P. ; Heidenreich, W.F.

Possible Implications of Non-Linear Radiobiological Effects for the Estimation of Radiation Risk at Low Doses.

Radiat. Prot. Dosim. 99, 279-281 (2002)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Possible implications of the effects of low LET radiation on the induction of cancer at low doses are studied Low dose hypersensitivity and adaptive response were identified as candidates which may give a non-linear dose effect curve for acute exposures. whereas adaptive response may influence protracted exposures. In this paper acute exposures are studied. Several radiobiological reports on studies with mammalian cell lines have indicated the presence of a hypersensitive region in the radiation survival response at low doses followed by an increase in radioresistance. The two step clonal expansion (TSCE) model for the process of carcinogenesis was adapted in such a way that cell killing after acute radiation induces increased clonal expansion for some time and thus gives a promoting effect of radiation. As a first step, the Radiation Effects Research Foundation (RERF) data on the lung cancer incidence are fitted to Study how such a model would influence the assessment of the cancer risk at low doses.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Schlagwörter hypersensitivity
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Zeitschrift Radiation Protection Dosimetry
Quellenangaben Band: 99, Heft: , Seiten: 279-281 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)