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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Simulation of DNA Damage after Proton and Low Let Irradiation.
Radiat. Prot. Dosim. 99, 99-102 (2002)
A module for proton track structure simulation in liquid water was implemented in the biophysical model PARTRAC. Simulated tracks of energy deposition events from the radiation under investigation were superimposed on a higher-order DNA target model describing the whole genome inside a human cell. The parameters controlling DNA damage from direct and indirect effects were adapted to agree with yields and pathway contributions derived from gamma ray irradiation experiments. Single and double strand break (DSB) induction Was Simulated for irradiations by protons, photon, and electrons over a wide range of initial energies. The relative biological effectiveness for DSB induction after proton irradiation was found to rise from 1.2 at 5 keV mum(-1) to about 2.5 at 70 keV.mum(-1). About half of this grown resulted from an increased production of DSB clusters associated with Small (< 10 kbp) fragments.
Impact Factor
Scopus SNIP
0.768
0.000
Anmerkungen
Besondere Publikation
Auf Hompepage verbergern
Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
DOUBLE-STRAND BREAKS; DSB INDUCTION; LIQUID WATER; ELECTRON TRACKS; CROSS-SECTIONS; SINGLE-STRAND; ENERGY; CELLS; DEPENDENCE; PHOTONS
Sprache
englisch
Veröffentlichungsjahr
2002
HGF-Berichtsjahr
0
ISSN (print) / ISBN
0144-8420
e-ISSN
1742-3406
Zeitschrift
Radiation Protection Dosimetry
Quellenangaben
Band: 99,
Seiten: 99-102
Verlag
Oxford University Press
Verlagsort
Oxford
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Radiation Protection (ISS)
POF Topic(s)
30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Forschungsfeld(er)
Radiation Sciences
PSP-Element(e)
G-501100-004
Erfassungsdatum
2002-09-11