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Friedland, W. ; Bernhardt, Ph. ; Jacob, P. ; Paretzke, H.G. ; Dingfelder, M.*

Simulation of DNA Damage after Proton and Low Let Irradiation.

Radiat. Prot. Dosim. 99, 99-102 (2002)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A module for proton track structure simulation in liquid water was implemented in the biophysical model PARTRAC. Simulated tracks of energy deposition events from the radiation under investigation were superimposed on a higher-order DNA target model describing the whole genome inside a human cell. The parameters controlling DNA damage from direct and indirect effects were adapted to agree with yields and pathway contributions derived from gamma ray irradiation experiments. Single and double strand break (DSB) induction Was Simulated for irradiations by protons, photon, and electrons over a wide range of initial energies. The relative biological effectiveness for DSB induction after proton irradiation was found to rise from 1.2 at 5 keV mum(-1) to about 2.5 at 70 keV.mum(-1). About half of this grown resulted from an increased production of DSB clusters associated with Small (< 10 kbp) fragments.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter DOUBLE-STRAND BREAKS; DSB INDUCTION; LIQUID WATER; ELECTRON TRACKS; CROSS-SECTIONS; SINGLE-STRAND; ENERGY; CELLS; DEPENDENCE; PHOTONS
ISSN (print) / ISBN 0144-8420
e-ISSN 1742-3406
Zeitschrift Radiation Protection Dosimetry
Quellenangaben Band: 99, Heft: , Seiten: 99-102 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)