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de Bartolo, D.* ; Cantone, M.C.* ; Giussani, A.* ; Garlaschelli, L.* ; Roth, P. ; Werner, E.

Determination of biokinetic parameters for ingestion of radionuclides of zirconium in animals using stable tracers.

Radiat. Environ. Biophys. 39, 53-58 (2000)
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Exposure to the radioactive isotope Zr-95, as in nuclear accidents, and to stable zirconium, due to its use in industry, has increased the interest in the biokinetics of this element. Information has been derived mainly from tests performed on animals by means of radioactive tracers. Due to the fact that extrapolation from animals to humans is always open to question, there is an increasing need of a methodology which allows data to be obtained directly from humans. The use of stable tracers, being ethically justifiable, is a powerful tool for providing this information. As two tracers of the same element must be utilized in order to evaluate gut absorption, an analytical technique which is capable of distinguishing and measuring simultaneously different isotopes of zirconium in biological samples is required. Preliminary tests on laboratory animals were performed in order to assess the feasibility of the double tracer technique combined with proton activation analysis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Biokinetics; Internal dose; Intestinal absorption; Stable tracers; Zirconium
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Zeitschrift Radiation and Environmental Biophysics
Quellenangaben Band: 39, Heft: , Seiten: 53-58 Artikelnummer: , Supplement: ,
Verlag Springer
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Radiation Protection (ISS)