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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Integrated view on 17beta-hydroxysteroid dehydrogenases.
Mol. Cell. Endocrinol. 301, (Sp. Iss. SI), 7-19 (2009)
17beta-Hydroxysteroid dehydrogenases (17beta-HSDs) are important enzymes in steroid metabolism. Long known members of the protein family seemed to be well characterised concerning their role in the regulation of the biological potency of steroid hormones, but today more and more evidence points to pivotal contributions of these enzymes in a variety of other metabolic pathways. Therefore, studies on 17beta-HSDs develop towards metabolomic survey. Latest research results give new insights into the complex metabolic interconnectivity of the 17beta-HSDs. In this paper metabolic activities of 17beta-HSDs will be compared, their interplay with endogenous substrates summarised, and interlacing pathways depicted. Strategies on deciphering the physiological role of 17beta-HSDs and the genetic predisposition for associated diseases will be presented.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Steroid metabolism; 17beta-Hydroxysteroid dehydrogenase; Multifunctionality; human 17-beta-hydroxysteroid dehydrogenase; peroxisomal multifunctional protein-2; polycystic-ovary-syndrome; coenzyme-a dehydrogenase; amyloid-beta-peptide; short-chain dehydrogenases/reductases; single-nucleotide polymorphisms; keto reductase superfamily; steroid-hormone metabolism; french-canadian families
ISSN (print) / ISBN
0303-7207
e-ISSN
1872-8057
Zeitschrift
Molecular and Cellular Endocrinology
Quellenangaben
Band: 301,
Heft: 1-2,
Seiten: 7-19,
Supplement: (Sp. Iss. SI)
Verlag
Elsevier
Verlagsort
Shannon
Begutachtungsstatus
Peer reviewed
Institut(e)
Molekulare Endokrinologie und Metabolismus (MEM)