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17ß-hydroxysteroid dehydrogenase type 7 - an ancient 3-ketosteroid reductase of cholesterogenesis.
Mol. Cell. Endocrinol. 171, 199-204 (2001)
17 beta -hydroxysterold dehydrogenase type 7 (17 beta -HSD7) is a novel estrogenic hydroxysteroid dehydrogenase from mammals. We modeled the three-dimensional structure of human 17 beta -HSD7, analyzed the phylogeny of 17 beta -HSD7 homologues and determined its expression pattern by in silico Northern blotting. Predominant expression is found not only in reproductive tissues (breast, ovary, placenta) but also in liver and developing brain, principal sites of cholesterol synthesis. The substrate binding pocket is opening towards a conserved membrane-associated helix, which is indicative for a conversion of a membrane component. 17 beta -HSD7 shows significant homology to a yeast 3-ketosteroid reductase (ERG27) involved in ergosterol biosynthesis. Our results lead to the conclusion that 17 beta -HSD7 is not only involved in estradiol production but plays another land possibly more important) role as a 3-ketosteroid reductase in cholesterogenesis. This agrees with the striking absence of 17 beta -HSD7 homologues in the complete genomes of Drosophila and C. elegans which are both auxotrophic for cholesterol.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
17ß-hydrosteroid dehydrogenase; 3-ketosteroid reductase; cholesterogenesis; steroidogenesis; evolution; HSD17B7
ISSN (print) / ISBN
0303-7207
e-ISSN
1872-8057
Zeitschrift
Molecular and Cellular Endocrinology
Quellenangaben
Band: 171,
Seiten: 199-204
Verlag
Elsevier
Verlagsort
Shannon
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Experimental Genetics (IEG)