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Pihusch, R.* ; Holler, E.* ; Mühlbayer, D.* ; Göhring, P.* ; Stötzer, O.* ; Hiller, E.* ; Kolb, H.-J.

The impact of antithymocyte globulin on short-term toxicity after allogenic stem cell transplantation.

Bone Marrow Transplant. 30, 347-354 (2002)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Antithymocyte globulin (ATG) is commonly used in allogeneic haematopoietic stem cell transplantation (HSCT). Little information is available, however, as to the optimal protocol for use and the side-effects occurring if ATG is administered in high daily doses (10-30 mg/kg). We report our experience with ATG Fresenius (ATG-F) in conditioning for allogeneic HSCT. During a period of 3 days, 47 patients received doses between 10 and 30 mg/kg either over 4 h preceded by 1-1.5 mg/kg prednisolone 30 min before the start of ATG-F (protocol A) or alternatively, over 12 h with 3-4 mg/kg prednisolone being administered before and 6 h after start of ATG (protocol B). During treatment with ATG-F, the side-effects observed included inflammation, disseminated intravascular coagulation, hyperdynamic circulation and renal dysfunction. Although these complications caused substantial morbidity, they were reversible within a few days. Side-effects were significantly more severe in patients treated according to protocol A than in those treated according to protocol B. As prolonged infusion of ATG-F does not reduce T cell clearance due to the long half-life of ATG-F, and since less cytokine release during conditioning might have beneficial long-term effects, we recommend administering ATG-F over 12 h preceded by high-dose steroid treatment.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter antithymocyte globulin; side-effects; treatment; transplantation
ISSN (print) / ISBN 0268-3369
e-ISSN 1476-5365
Zeitschrift Bone Marrow Transplantation
Quellenangaben Band: 30, Heft: 6, Seiten: 347-354 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) CCG Hematopoetic Cell Transplants (IMI-KHZ)