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Random ENU Mutagenesis.
Methods Mol. Biol. 209, 249-266 (2003)
Mouse models play an important role in the elucidation of molecular pathways underlying human disease. Mutations in mouse can be generated by a variety of techniques including those using inducing agents such ionizing radiation or chemicals and those that involve genetic manipulations such as transgenic insertions or knockouts. Random mutagenesis by ionizing radiation or chemical agents has a long tradition in classical genetics and has allowed the generation of a large number of mutant phenotypes. Ionizing radiation causes breaks in the chromosome, leading to deletions, translocations, and other gross chromosomal rearrangements. Chemical mutagens, which have been shown to produce a large number of mutations, are characterised by a differential spermatogenic response.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Herausgeber
Hofker, M.H.* ; Deursen, J.*
ISSN (print) / ISBN
1064-3745
e-ISSN
1940-6029
Konferenztitel
Transgenic Mouse : Methods and Protocols
Zeitschrift
Methods in Molecular Biology
Quellenangaben
Band: 209,
Seiten: 249-266
Verlag
Springer
Verlagsort
Berlin [u.a.]
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Experimental Genetics (IEG)