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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Fate specification in the adult brain lessons for eliciting neurogenesis from glial cells.
Bioessays 35, 242-252 (2013)
In the adult mammalian brain, neurogenesis is restricted to few regions, while gliogenesis continues in a wide-spread manner. Here we discuss our knowledge of extrinsic and intrinsic factors regulating neuro- and gliogenesis in the adult brain and propose a model of fate specification identifying the states of easiest transition between glio- and neurogenesis, highlighting the unique mechanisms stabilising the neural stem cell state. The model also encompasses the fate alterations achieved by direct reprogramming, and hence addresses a novel avenue for repair, namely eliciting neurogenesis from glial cells outside the neurogenic niches.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Fate Commitment ; Lineage ; Neural Stem Cell ; Neurogenesis; Neural Stem-cells ; Fibroblast Growth Factor-2 ; Nuclear Receptor Tlx ; Bone Morphogenetic Proteins ; In-vivo ; Subventricular Zone ; Self-renewal ; Hippocampal Neurogenesis ; Lineage Plasticity ; Progenitor Cells
ISSN (print) / ISBN
0265-9247
e-ISSN
1521-1878
Zeitschrift
BioEssays
Quellenangaben
Band: 35,
Heft: 3,
Seiten: 242-252
Verlag
Wiley
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)