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Wermter, A.K.* ; Scherag, A.* ; Meyre, D.* ; Reichwald, K.* ; Durand, E.* ; Nguyen, T.T.* ; Koberwitz, K. ; Lichtner, P. ; Meitinger, T. ; Schäfer, H.* ; Hinney, A.* ; Froguel, P.* ; Hebebrand, J.* ; Brönner, G.*

Preferential reciprocal transfer of paternal/maternal DLK1 alleles to obese children: First evidence of polar overdominance in humans.

Eur. J. Hum. Genet. 16, 1126-1134 (2008)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
DLK1 is part of the Notch signalling pathway that controls various developmental processes. A functional role for DLK1 in adipogenesis is suggested by several animal models. Interestingly, the DLK1 gene is imprinted in eutherian mammals. To study whether variations in DLK1 affect body weight in humans, we analysed 32 polymorphisms in a 109 kb genomic region encompassing DLK1 on human chromosome 14. In a study sample of 1025 French and German trio families comprised of both parents and extremely obese offspring we found a single nucleotide polymorphism (rs1802710) associated with child and adolescent obesity. Analysis of the allelic transmission pattern indicated the existence of polar overdominance, an unusual mode of non-Mendelian inheritance in humans previously known from the callipyge mutation in sheep.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter genetics; imprinting; obesity
ISSN (print) / ISBN 1018-4813
e-ISSN 1476-5438
Quellenangaben Band: 16, Heft: 9, Seiten: 1126-1134 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed