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Deshpande, A.J. ; Cusan, M. ; Rawat, V.P.S. ; Reuter, H. ; Krause, A. ; Pott, C.* ; Quintanilla-Martinez, L. ; Kakadia, P. ; Kuchenbauer, F. ; Ahmed, F. ; Delabesse, E.* ; Hahn, M.* ; Lichtner, P.* ; Kneba, M. ; Hiddemann, W. ; Macintyre, E.* ; Mecucci, C.* ; Ludwig, W.D.* ; Humphries, R.K.* ; Bohlander, S.K. ; Feuring-Buske, M. ; Buske, C.

Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia.

Cancer Cell 10, 363-374 (2006)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
A challenge for the development of therapies selectively targeting leukemic stem cells in acute myeloid leukemia (AML) is their similarity to normal hematopoietic stem cells (HSCs). Here we demonstrate that the leukemia-propagating cell in murine CALM/AF10-positive AML differs from normal HSCs by B220 surface expression and immunoglobulin heavy chain rearrangement. Furthermore, depletion of B220+ cells in leukemic transplants impaired development of leukemia in recipients. As in the murine model, human CALM/AF10-positive AML was characterized by CD45RA (B220)-positive, IG DH-JH rearranged leukemic cells. These data demonstrate in a murine leukemia model that AML can be propagated by a transformed progenitor with lymphoid characteristics, which can be targeted by antibodies that do not crossreact with normal HSCs. © 2006 Elsevier Inc. All rights reserved.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Humdisease
ISSN (print) / ISBN 1535-6108
e-ISSN 1878-3686
Zeitschrift Cancer Cell
Quellenangaben Band: 10, Heft: 5, Seiten: 363-374 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed