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Ninkovic, J. ; Götz, M.

How to make neurons-thoughts on the molecular logic of neurogenesis in the central nervous system.

Cell Tissue Res. 359, 5-16 (2015)
Verlagsversion DOI PMC
Free by publisher
Neuronal differentiation relies on a set of interconnected molecular events to achieve the differentiation of pan-neuronal hallmarks, together with neuronal subtype-specific features. Here, we propose a conceptual framework for these events, based on recent findings. This framework encompasses a dimension in time during development, progressing from early master regulators to later expressed effector genes and terminal selector genes. As a horizontal intersection, we propose the action of permissive fate determinants that are critical in allowing progression through the above transcriptional phases. Typically, these are widely expressed and often interact with the chromatin remodeling machinery. We conclude by discussing this model in the context of the direct fate conversion of various somatic cells into neurons.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Central Nervous System ; Direct Conversion ; Fate Determinant ; Fate Specification ; Neurogenesis ; Transcription Factor; Neural Stem-cells; Adult Hippocampal Neurogenesis; Soxc Transcription Factors; In-vivo; Dopaminergic-neurons; Olfactory-bulb; Fate Specification; Glial-cells; Progenitor Proliferation; Functional-neurons
ISSN (print) / ISBN 0044-3794
e-ISSN 1432-0878
Zeitschrift Cell and Tissue Research
Quellenangaben Band: 359, Heft: 1, Seiten: 5-16 Artikelnummer: , Supplement: ,
Verlag Springer
Verlagsort New York
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)