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Götz, M. ; Nakafuku, M. ; Petrik, D.

Neurogenesis in the developing and adult brain - similarities and key differences.

Cold Spring Harbor Perspect. Biol. 8, DOI: 10.1101/cshperspect.a018853 (2015)
DOI PMC
Adult neurogenesis in the mammalian brain is often viewed as a continuation of neurogenesis at earlier, developmental stages. Here, we will critically review the extent to which this is the case highlighting similarities as well as key differences. Although many transcriptional regulators are shared in neurogenesis at embryonic and adult stages, recent findings on the molecular mechanisms by which these neuronal fate determinants control fate acquisition and maintenance have revealed profound differences between development and adulthood. Importantly, adult neurogenesis occurs in a gliogenic environment hence requiring adult-specific additional and unique mechanisms of neuronal fate specification and maintenance. Thus, a better understanding of the molecular logic for continuous adult neurogenesis provides important clues to develop strategies to manipulate endogenous stem cells for the purpose of repair.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Herausgeber Gage, F.H.* ; Kempermann, G.* ; Song, H.*
Korrespondenzautor
Schlagwörter Neural Stem-cells; Metabotropic Glutamate Receptors; Postnatal Subventricular Zone; Olfactory-bulb Neurogenesis; Lateral Ganglionic Eminence; Transcription Factor Pax6; Rat Dentate Gyrus; Central-nervous-system; Mammalian Spinal-cord; Homeobox Gene Gsx2
e-ISSN 1943-0264
Konferenztitel Additional Perspectives on Neurogenesis
Zeitschrift Cold Spring Harbor Perspectives in Biology
Quellenangaben Band: 8, Heft: 7 Seiten: , Artikelnummer: , Supplement: ,
Verlag Cold Spring Harbor Laboratory Press
Verlagsort Cold Spring Harbor
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)