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Huerta-Cepas, J.* ; Szklarczyk, D.* ; Forslund, K.* ; Cook, H.* ; Heller, D.* ; Walter, M.C. ; Rattei, T.* ; Mende, D.R.* ; Sunagawa, S.* ; Kuhn, M.* ; Jensen, L.J.* ; von Mering, C.* ; Bork, P.*

eggNOG 4.5: A hierarchical orthology framework with improved functional annotations for eukaryotic, prokaryotic and viral sequences.

Nucleic Acids Res. 44, D286-D293 (2016)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
eggNOG is a public resource that provides Orthologous Groups (OGs) of proteins at different taxonomic levels, each with integrated and summarized functional annotations. Developments since the latest public release include changes to the algorithm for creating OGs across taxonomic levels, making nested groups hierarchically consistent. This allows for a better propagation of functional terms across nested OGs and led to the novel annotation of 95 890 previously uncharacterized OGs, increasing overall annotation coverage from 67% to 72%. The functional annotations of OGs have been expanded to also provide Gene Ontology terms, KEGG pathways and SMART/Pfam domains for each group. Moreover, eggNOG now provides pairwise orthology relationships within OGs based on analysis of phylogenetic trees. We have also incorporated a framework for quickly mapping novel sequences to OGs based on precomputed HMM profiles. Finally, eggNOG version 4.5 incorporates a novel data set spanning 2605 viral OGs, covering 5228 proteins from 352 viral proteomes. All data are accessible for bulk downloading, as a web-service, and through a completely redesigned web interface. The new access points provide faster searches and a number of new browsing and visualization capabilities, facilitating the needs of both experts and less experienced users.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Protein Families; Cog Database; Genome-wide; Genes; Software; Tree; Representation; Duplication; Performance; Alignments
ISSN (print) / ISBN 0305-1048
e-ISSN 1362-4962
Quellenangaben Band: 44, Heft: D1, Seiten: D286-D293 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Oxford
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed