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Weber, A.* ; Heikenwälder, M.

P(URI)fying novel drivers of NASH and HCC: A feedforward loop of IL17A via white adipose tissue.

Cancer Cell 30, 15-17 (2016)
Verlagsversion DOI PMC
Free by publisher
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
How obesity and metabolic syndrome trigger non-alcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC) remains elusive. In this issue, Gomes and colleagues describe that nutrient surplus induces hepatic URI expression, triggering genotoxicity and IL17A expression, thus leading to insulin resistance, NASH, and HCC. IL17A signaling blockers might become a readily translatable therapy.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Editorial
Korrespondenzautor
Schlagwörter Hepatocellular-carcinoma; Liver; Tumorigenesis; Epidemiology; Prevention; Cancer; Cells; Uri
ISSN (print) / ISBN 1535-6108
e-ISSN 1878-3686
Zeitschrift Cancer Cell
Quellenangaben Band: 30, Heft: 1, Seiten: 15-17 Artikelnummer: , Supplement: ,
Verlag Cell Press
Verlagsort Cambridge, Mass.
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Virology (VIRO)