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Secreted interferon-inducible factors restrict hepatitis B and C virus entry in vitro.
J. Immunol. Res. 2017:4828936 (2017)
Interferon-α (IFN-α) has been used for more than 20 years as the first-line therapy for hepatitis B virus (HBV) and hepatitis C virus (HCV) infection, because it has a number of antiviral effects. In this study, we describe a novel mode of its antiviral action. We demonstrate that the supernatant from IFN-α-treated cultured cells restricted HBV and HCV infection by inhibiting viral entry into hepatoma cells. The factors contained in the supernatant competed with the virus for binding to heparan glycosaminoglycans-the nonspecific attachment step shared by HBV and HCV. Secreted factors of high molecular mass that bind to heparin columns elicited the antiviral effect. In conclusion, IFN-α is able to induce soluble factors that can bind to heparan glycosaminoglycans thus leading to the inhibition of viral binding.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Surface Heparan-sulfate; Humanized Mice; Initial Interaction; Envelope Protein; Dengue Virus; Infection; Replication; Binding; Cells; Identification
ISSN (print) / ISBN
2314-8861
e-ISSN
2314-7156
Zeitschrift
Journal of Immunology Research
Quellenangaben
Band: 2017,
Artikelnummer: 4828936
Verlag
Hindawi
Verlagsort
New York, NY
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Virology (VIRO)