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Heimann, G.* ; Lange Canhos, L. ; Frik, J. ; Jäger, G.* ; Lepko, T. ; Ninkovic, J. ; Götz, M. ; Sirko, S.

Changes in the proliferative program limit astrocyte Hhmeostasis in the aged post-traumatic murine cerebral cortex.

Cereb. Cortex 27, 1-16 (2017)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Aging leads to adverse outcomes after traumatic brain injury. The mechanisms underlying these defects, however, are not yet clear. In this study, we found that astrocytes in the aged post-traumatic cerebral cortex develop a significantly reduced proliferative response, resulting in reduced astrocyte numbers in the penumbra. Moreover, experiments of reactive astrocytes in vitro reveal that their diminished proliferation is due to an age-related switch in the division mode with reduced cell-cycle re-entry rather than changes in cell-cycle length. Notably, reactive astrocytes in vivo and in vitro become refractory to stimuli increasing their proliferation during aging, such as Sonic hedgehog signaling. These data demonstrate for the first time that age-dependent, most likely intrinsic changes in the proliferative program of reactive astrocytes result in their severely hampered proliferative response to traumatic injury thereby affecting astrocyte homeostasis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Gfap ; Shh ; Aging ; Brain Injury ; Cell Division ; Glia ; Reactive Gliosis ; Self-renewal; Neural Stem-cells; Fibrillary Acidic Protein; Central-nervous-system; Glutamine-synthetase; Alzheimers-disease; Ischemic-stroke; Aging Brain; Functional Recovery; Reactive Gliosis; Transgenic Mice
ISSN (print) / ISBN 1047-3211
e-ISSN 1460-2199
Zeitschrift Cerebral Cortex
Quellenangaben Band: 27, Heft: 8, Seiten: 1-16 Artikelnummer: , Supplement: ,
Verlag Oxford University Press
Verlagsort Cary
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)