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Kick, K.* ; Ziegler, A.-G.

Immune preventive approaches for type-1-diabetes.

Med. Monatsschr. Pharm. 41, 105-109 (2018)
DOI
Type-1-diabetes is one of the most common chronic diseases of childhood. Children with type-1-diabetes need life-long insulin treatment, with enormous consequences for the child and its family. Years to months before clinical symptoms of type-1-diabetes onset appear, subclinical destruction of the insulin producing beta cells takes place. This process is identified by circulating islet autoantibodies to beta cell antigens, and is mediated by a lack of immunological tolerance [20]. Several immune preventive approaches could already show that administration of the antigen insulin delays type-1-diabetes onset by involving the induction of insulin-specific regulatory T cells [5, 7] . Antigen-specific therapy with insulin before or immediately after the development of autoantibodies may induce the protective immune response that prevents the emergence of autoimmunity and type-1-diabetes.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
ISSN (print) / ISBN 0342-9601
Zeitschrift Medizinische Monatsschrift für Pharmazeuten
Quellenangaben Band: 41, Heft: 3, Seiten: 105-109 Artikelnummer: , Supplement: ,
Verlag Dt. Apotheker Verl.
Verlagsort Stuttgart
Nichtpatentliteratur Publikationen
Institut(e) Institute of Diabetes Research Type 1 (IDF)