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A chromatin-based signalling mechanism directs the switch from mutagenic to error-free repair of DNA double strand breaks.
Mol. Cell. Oncol. 6:1605820 (2019)
Mutations caused by DNA damage are a main driver of cancer. We discovered that recognition of newly synthesised histone H4 directs breast cancer type 1 susceptibility protein (BRCA1) to post-replicative chromatin. The switch from mutagenic to error-free DNA double strand break repair by homologous recombination is therefore controlled by chromatin.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Sonstiges: Meinungsartikel
Schlagwörter
53bp1 ; Bard1 ; Brca1 ; Dna Double Strand Break Repair ; Homologous Recombination
e-ISSN
2372-3556
Zeitschrift
Molecular & Cellular Oncology
Quellenangaben
Band: 6,
Heft: 4,
Artikelnummer: 1605820
Verlag
Taylor & Francis
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Functional Epigenetics (IFE)