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Lepko, T. ; Pusch, M. ; Müller, T.* ; Schulte, D.* ; Ehses, J.* ; Kiebler, M.* ; Hasler, J. ; Huttner, H.B.* ; Vandenbroucke, R.E.* ; Vandendriessche, C.* ; Modic, M.* ; Martin-Villalba, A.* ; Zhao, S.* ; LLorens-Bobadilla, E.* ; Schneider, A.* ; Fischer, A.* ; Breunig, C. ; Stricker, S.H. ; Götz, M. ; Ninkovic, J.

Choroid plexus-derived miR-204 regulates the number of quiescent neural stem cells in the adult brain.

EMBO J. 38:e100481 (2019)
Verlagsversion Preprint Forschungsdaten DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Regulation of adult neural stem cell (NSC) number is critical for lifelong neurogenesis. Here, we identified a post-transcriptional control mechanism, centered around the microRNA 204 (miR-204), to control the maintenance of quiescent (q)NSCs. miR-204 regulates a spectrum of transcripts involved in cell cycle regulation, neuronal migration, and differentiation in qNSCs. Importantly, inhibition of miR-204 function reduced the number of qNSCs in the subependymal zone (SEZ) by inducing pre-mature activation and differentiation of NSCs without changing their neurogenic potential. Strikingly, we identified the choroid plexus of the mouse lateral ventricle as the major source of miR-204 that is released into the cerebrospinal fluid to control number of NSCs within the SEZ. Taken together, our results describe a novel mechanism to maintain adult somatic stem cells by a niche-specific miRNA repressing activation and differentiation of stem cells.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adult Neurogenesis ; Mir-204 ; Neural Stem Cells ; Neurogenesis ; Neurogenic Priming; Cerebrospinal-fluid; Neuronal Differentiation; Subventricular Zone; Progenitor Cells; Fate Specification; Embryonic Origin; Neurogenesis; Niche; Migration; Transplantation
ISSN (print) / ISBN 0261-4189
e-ISSN 1460-2075
Zeitschrift EMBO Journal, The
Quellenangaben Band: 38, Heft: 17, Seiten: , Artikelnummer: e100481 Supplement: ,
Verlag Wiley
Verlagsort Heidelberg, Germany
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)