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Conrad, M. ; Pratt, D.A.*

The chemical basis of ferroptosis.

Nat. Chem. Biol. 15, 1137-1147 (2019)
DOI
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Lipid peroxidation underlies the mechanism of oxidative cell death now known as ferroptosis. This modality, distinct from other forms of cell death, has been intensely researched in recent years owing to its relevance in both degenerative disease and cancer. The demonstration that it can be modulated by small molecules in multiple pathophysiological contexts offers exciting opportunities for novel pharmacological interventions. Herein, we introduce the salient features of lipid peroxidation, how it can be modulated by small molecules and what principal aspects require urgent investigation by researchers in the field. The central role of non-enzymatic reactions in the execution of ferroptosis will be emphasized, as these processes have hitherto not been generally considered 'druggable'. Moreover, we provide a critical perspective on the biochemical mechanisms that contribute to cell vulnerability to ferroptosis and discuss how they can be exploited in the design of novel therapeutics.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Polyunsaturated Fatty-acids; Cell-death; Lipid-peroxidation; Cancer-cells; Cystine/glutamate Antiporter; Oxidative Stress; Tumor-growth; Autoxidation; Mechanisms; Antioxidant
ISSN (print) / ISBN 1552-4450
e-ISSN 1552-4469
Zeitschrift Nature Chemical Biology
Quellenangaben Band: 15, Heft: 12, Seiten: 1137-1147 Artikelnummer: , Supplement: ,
Verlag Nature Publishing Group
Verlagsort Basingstoke
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Developmental Genetics (IDG)