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Eklund, N.* ; Andrianarisoa, N.H.* ; van Enckevort, E.* ; Anton, G. ; Debucquoy, A.* ; Mueller, H.* ; Zaharenko, L.* ; Engels, C.* ; Ebert, L.* ; Neumann, M.* ; Geeraert, J.* ; T'Joen, V.* ; Demski, H. ; Caboux, E.* ; Proynova, R.* ; Parodi, B.* ; Mate, S.* ; van Iperen, E.* ; Merino-Martinez, R.* ; Quinlan, P.R.* ; Holub, P.* ; Silander, K.*

Extending the minimum information about bIobank data sharing terminology to describe samples, sample donors, and events.

Biopreserv. Biobank. 18, 155-164 (2020)

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Introduction: The Minimum Information About BIobank data Sharing (MIABIS) was initiated in 2012. MIABIS aims to create a common biobank terminology to facilitate data sharing in biobanks and sample collections. The MIABIS Core terminology consists of three components describing biobanks, sample collections, and studies, in which information on samples and sample donors is provided at aggregated form. However, there is also a need to describe samples and sample donors at an individual level to allow more elaborate queries on available biobank samples and data. Therefore the MIABIS terminology has now been extended with components describing samples and sample donors at an individual level. Materials and Methods: The components were defined according to specific scope and use cases by a large group of experts, and through several cycles of reviews, according to the new MIABIS governance model of BBMRI-ERIC (Biobanking and Biomolecular Resources Research Infrastructure-European Research Infrastructure Consortium). The guiding principles applied in developing these components included the following terms: model should consider only samples of human origin, model should be applicable to all types of samples and all sample donors, and model should describe the current status of samples stored in a given biobank. Results: A minimal set of standard attributes for defining samples and sample donors is presented here. We added an "event" component to describe attributes that are not directly describing samples or sample donors but are tightly related to them. To better utilize the generic data model, we suggest a procedure by which interoperability can be promoted, using specific MIABIS profiles. Discussion: The MIABIS sample and donor component extensions and the new generic data model complement the existing MIABIS Core 2.0 components, and substantially increase the potential usability of this terminology for better describing biobank samples and sample donors. They also support the use of individual level data about samples and sample donors to obtain accurate and detailed biobank availability queries.

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