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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The stem cell potential of glia: Lessons from reactive gliosis.
Nat. Rev. Neurosci. 12, 88-104 (2011)
Astrocyte-like cells, which act as stem cells in the adult brain, reside in a few restricted stem cell niches. However, following brain injury, glia outside these niches acquire or reactivate stem cell potential as part of reactive gliosis. Recent studies have begun to uncover the molecular pathways involved in this process. A comparison of molecular pathways activated after injury with those involved in the normal neural stem cell niches highlights strategies that could overcome the inhibition of neurogenesis outside the stem cell niche and instruct parenchymal glia towards a neurogenic fate. This new view on reactive glia therefore suggests a widespread endogenous source of cells with stem cell potential, which might potentially be harnessed for local repair strategies.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
central-nervous-system; epidermal-growth-factor; spinal-cord-injury; neural stem/progenitor cells; adult-rat brain; oligodendrocyte precursor cells; subventricular zone astrocytes; bone morphogenetic proteins; in-vitro; cerebral-cortex
ISSN (print) / ISBN
1471-003X
e-ISSN
1471-0048
Zeitschrift
Nature Reviews - Neuroscience
Quellenangaben
Band: 12,
Heft: 2,
Seiten: 88-104
Verlag
Nature Publishing Group
Verlagsort
London
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Stem Cell Research (ISF)