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Villalba, A.* ; Götz, M. ; Borrell, V.*

The regulation of cortical neurogenesis.

Curr. Top. Dev. Biol. 142, 1-66 (2020)
DOI PMC
Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
The mammalian cerebral cortex is the pinnacle of brain evolution, reaching its maximum complexity in terms of neuron number, diversity and functional circuitry. The emergence of this outstanding complexity begins during embryonic development, when a limited number of neural stem and progenitor cells manage to generate myriads of neurons in the appropriate numbers, types and proportions, in a process called neurogenesis. Here we review the current knowledge on the regulation of cortical neurogenesis, beginning with a description of the types of progenitor cells and their lineage relationships. This is followed by a review of the determinants of neuron fate, the molecular and genetic regulatory mechanisms, and considerations on the evolution of cortical neurogenesis in vertebrates leading to humans. We finish with an overview on how dysregulation of neurogenesis is a leading cause of human brain malformations and functional disabilities.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Apical Adherens Junction ; Ferret ; Folding ; Intermediate Progenitor Cell ; Pax6 ; Radial Glia; Radial Glial-cells; Neural Stem-cells; Outer Subventricular Zone; Intermediate Progenitor Cells; Developing Cerebral-cortex; Central-nervous-system; Neocortical Projection Neurons; Protein Response Contributes; Messenger-rna Transport; Transcription Factor
ISSN (print) / ISBN 0070-2153
e-ISSN 1557-8933
Zeitschrift Current Topics in Developmental Biology
Quellenangaben Band: 142, Heft: , Seiten: 1-66 Artikelnummer: , Supplement: ,
Verlag Elsevier
Verlagsort 525 B Street, Suite 1900, San Diego, Ca 92101-4495 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Stem Cell Research (ISF)
Förderungen "Severo Ochoa" Programme for Centers of Excellence in RD
ERC Advanced Grant ChroNeuroRepair
Spanish State Research Agency
ERC Consolidator Grant CORTEXFOLDING