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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Extracellular vesicles released by myeloid-derived suppressor cells from pregnant women modulate adaptive immune responses.
Cell. Immunol. 361:104276 (2021)
Immunological pregnancy complications are a main challenge in reproductive medicine. Mechanisms regulating the adaptation of the maternal immune system to pregnancy are incompletely understood and therapeutic options limited. Myeloid derived suppressor cells (MDSC) are immune-modulatory cells expanding during healthy pregnancy and seem to play a crucial role for maternal-fetal tolerance. Recent studies showed that exosomes produced by MDSC have immune-modulatory effects corresponding to their parental cells under different pathological conditions. Here, we investigated immunological effects of exosomes of GR-MDSC during pregnancy. Isolated GR-MDSC exosomes from peripheral blood of pregnant women were tested for functionality in different in vitro assays. We show that GR-MDSC exosomes exhibited profound immune-modulatory effects such as suppression of T-cell proliferation, T helper 2 (Th2)-cell polarization, induction of regulatory T-cells and inhibition of lymphocyte cytotoxicity. Our results confirm that MDSC-derived exosomes functionally correspond to their parental cells and identify them as an interesting therapeutic target for immunological pregnancy complications.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Wissenschaftlicher Artikel
Schlagwörter
Extracellular Vesicles ; Mdsc ; Pregnancy ; Th-cells ; Tregs
ISSN (print) / ISBN
0008-8749
e-ISSN
0008-8749
Zeitschrift
Cellular Immunology
Quellenangaben
Band: 361,
Artikelnummer: 104276
Verlag
Elsevier
Verlagsort
525 B St, Ste 1900, San Diego, Ca 92101-4495 Usa
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Förderungen
German Center for Infection Research (DZIF)
Federal Ministry of Education and Research (BMBF)
German Research Foundation (DFG)
European Social Fund
Ministry for Science, Research and Art Baden-Wurttemberg (MWK-BW)
Medical Faculty of Tuebingen University
Federal Ministry of Education and Research (BMBF)
German Research Foundation (DFG)
European Social Fund
Ministry for Science, Research and Art Baden-Wurttemberg (MWK-BW)
Medical Faculty of Tuebingen University