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New technologies for developing phage-based tools to manipulate the human microbiome.
Trends Microbiol. 30, 131-142 (2022)
Verlagsversion
DOI
PMC
Gut bacteria play an essential role in the human body by regulating multiple functions, producing essential metabolites, protecting against pathogen invasion, and much more. Conversely, changes in their community structure are linked to several gastrointestinal (GI) and non-GI conditions. Fortunately, these bacteria are amenable to external perturbations, but we need specific tools for their safe manipulation as nonspecific changes can cause unpredicted long-term consequences. Here, we mainly discuss recent advances in cultivation-independent technologies and argue their relevance to different key steps, that is, identifying the modulation targets and developing phage-based tools to precisely modulate gut bacteria and restore a sustainable microbiome in humans. We finally suggest multiple modulating strategies for different dysbiosis-associated diseases.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Cultivation-independent Technologies ; Microbiome Manipulation ; Multi-omics ; Phages ; Viral-tagging; Human Gut; Host-range; Bacteria; Metabolism; Bacteriophages; Cultivation; Resistance; Therapy; Patient
ISSN (print) / ISBN
0966-842X
e-ISSN
1878-4380
Zeitschrift
Trends in microbiology
Quellenangaben
Band: 30,
Heft: 2,
Seiten: 131-142
Verlag
Cell Press
Verlagsort
Cambridge, Mass.
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Virology (VIRO)
Förderungen
German Research Foundation (DFG Emmy Noether program)
European Research Council
European Research Council