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Ma, T. ; Ru, J. ; Xue, J. ; Schulz, S. ; Mirzaei, M.K. ; Janssen, K.P.* ; Quante, M.* ; Deng, L.

Differences in gut virome related to barrett esophagus and esophageal adenocarcinoma.

Microorganisms 9:1701 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
The relationship between viruses (dominated by bacteriophages or phages) and lower gastrointestinal (GI) tract diseases has been investigated, whereas the relationship between gut bacteriophages and upper GI tract diseases, such as esophageal diseases, which mainly include Barrett’s esophagus (BE) and esophageal adenocarcinoma (EAC), remains poorly described. This study aimed to reveal the gut bacteriophage community and their behavior in the progression of esophageal diseases. In total, we analyzed the gut phage community of sixteen samples from patients with esophageal diseases (six BE patients and four EAC patients) as well as six healthy controls. Differences were found in the community composition of abundant and rare bacteriophages among three groups. In addition, the auxiliary metabolic genes (AMGs) related to bacterial exotoxin and virulence factors such as lipopolysaccharides (LPS) biosynthesis proteins were found to be more abundant in the genome of rare phages from BE and EAC samples compared to the controls. These results suggest that the community composition of gut phages and functional traits encoded by them were different in two stages of esophageal diseases. However, the findings from this study need to be validated with larger sample sizes in the future.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Bacterial Exotoxin ; Esophageal Carcinogenesis ; Esophageal Diseases ; Gut Bacteriophages ; Lps Biosynthesis Proteins; Bacterial Biota; Bacteriophages; Microbiome; Viruses; Inflammation; Pathways; Health; Cancer
ISSN (print) / ISBN 2076-2607
e-ISSN 2076-2607
Zeitschrift Microorganisms
Quellenangaben Band: 9, Heft: 8, Seiten: , Artikelnummer: 1701 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Förderungen Deutsche Krebshilfe Max Eder Program
European Research Council
German Research Foundation (DFG Emmy Noether program)
The Deutsche Krebshilfe Max Eder Program
European Research Council starting grant