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Gjermeni, E.* ; Kirstein, A.S.* ; Kolbig, F.* ; Kirchhof, M.* ; Bundalian, L.* ; Katzmann, J.L.* ; Laufs, U.* ; Blüher, M. ; Garten, A.* ; Le Duc, D.

Obesity–an update on the basic pathophysiology and review of recent therapeutic advances.

Biomolecules 11:1426 (2021)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Obesity represents a major public health problem with a prevalence increasing at an alarming rate worldwide. Continuous intensive efforts to elucidate the complex pathophysiology and improve clinical management have led to a better understanding of biomolecules like gut hor-mones, antagonists of orexigenic signals, stimulants of fat utilization, and/or inhibitors of fat ab-sorption. In this article, we will review the pathophysiology and pharmacotherapy of obesity including intersection points to the new generation of antidiabetic drugs. We provide insight into the effectiveness of currently approved anti-obesity drugs and other therapeutic avenues that can be explored.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Review
Korrespondenzautor
Schlagwörter Anti-obesity Drugs ; Diabetes Mellitus ; Energy Balance ; Obesity ; Obesity Metabolism; Glucagon-like Peptide-1; Brown Adipose-tissue; Controlled-release Phentermine/topiramate; Gastric-inhibitory Polypeptide; Ghrelin Receptor Mutations; Type-2 Diabetes-mellitus; Diet-induced Obesity; Reduces Food-intake; Induced Weight-loss; Pancreatic-polypeptide
ISSN (print) / ISBN 2218-273X
e-ISSN 2218-273X
Zeitschrift Biomolecules
Quellenangaben Band: 11, Heft: 10, Seiten: , Artikelnummer: 1426 Supplement: ,
Verlag MDPI
Verlagsort Basel
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Förderungen Project DEAL
Clinician Scientist Programm, Medizinische Fakultaet der Universitaet Leipzig
German Research Foundation