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100 Years of insulin: Lifesaver, immune target, and potential remedy for prevention.
Med. 2, 1120-1137 (2021)
In this review, we bring our personal experiences to showcase insulin from its breakthrough discovery as a life-saving drug 100 years ago to its uncovering as the autoantigen and potential cause of type 1 diabetes and eventually as an opportunity to prevent autoimmune diabetes. The work covers the birth of insulin to treat patients, which is now 100 years ago; the development of human insulin, insulin analogs, devices, and the way into automated insulin delivery; the realization that insulin is the primary autoimmune target of type 1 diabetes in children; novel approaches of immunotherapy using insulin for immune tolerance induction; the possible limitations of insulin immunotherapy; and an outlook on how modern vaccines could remove the need for another 100 years of insulin therapy.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Autoimmunity ; Automated Insulin Delivery ; Insulin ; Insulin Autoantibody ; Insulin Device ; Insulin Immunotherapy ; Insulin Pump ; Tolerance ; Treg ; Type 1 Diabetes
ISSN (print) / ISBN
2666-6359
e-ISSN
2666-6340
Zeitschrift
Med (N Y)
Quellenangaben
Band: 2,
Heft: 10,
Seiten: 1120-1137
Verlag
Cell Press
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute for Pancreatic Beta Cell Research (IPI)
Institute of Diabetes Research Type 1 (IDF)
Type 1 Diabetes Immunology (TDI)
Institute of Diabetes Research Type 1 (IDF)
Type 1 Diabetes Immunology (TDI)
Förderungen
NIDDK NIH HHS