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Chen, Y.* ; Fernandez, E.A.* ; Röger, C.* ; Lopez-Mejia, I.C.* ; Fajas Coll, L.* ; Ji, H.

Adipocyte-specific CDK7 ablation leads to progressive loss of adipose tissue and metabolic dysfunction.

FEBS Lett. 596, 1434-1444 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Adipose tissue regulates whole-body energy homeostasis. Both lipodystrophy and obesity, the extreme and opposite aspects of adipose tissue dysfunction, result in metabolic disorders: insulin resistance and hepatic steatosis. Cyclin-dependent kinases (CDKs) have been reported to be involved in adipose tissue development and functions. Using adipose tissue-specific knockout mice, here we demonstrate that the deletion of CDK7 in adipose tissue results in progressive lipodystrophy, insulin resistance, impaired adipokine secretion and down-regulation of fat-specific genes, which are aggravated on high-fat diet and during aging. Our studies suggest that CDK7 is a key regulatory component of adipose tissue maintenance and systemic energy homeostasis.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adipose Tissue ; Cyclin-dependent Kinase 7 ; Lipid Metabolism ; Lipodystrophy
ISSN (print) / ISBN 0014-5793
e-ISSN 1873-3468
Zeitschrift FEBS Letters
Quellenangaben Band: 596, Heft: 11, Seiten: 1434-1444 Artikelnummer: , Supplement: ,
Verlag Elsevier
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Institute of Diabetes and Cancer (IDC)
Förderungen Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung