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Nückel, J.* ; Planatscher, E.* ; Mohr, A.W.* ; Deichl, K.* ; Mijočević, H. ; Feuerherd, M. ; Wolff, L.S. ; Erber, J.* ; Schneider, J.* ; Quante, M.* ; Winter, C.* ; Ruland, J.* ; Hapfelmeier, A.* ; Hammerschmidt, W. ; Moosmann, A.* ; Protzer, U. ; Behrends, U.* ; Mautner, J.

Association between IgG responses against the nucleocapsid proteins of alphacoronaviruses and COVID-19 severity.

Front. Immunol. 13:889836 (2022)
Verlagsversion DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Understanding immune responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is crucial to contain the COVID-19 pandemic. Using a multiplex approach, serum IgG responses against the whole SARS-CoV-2 proteome and the nucleocapsid proteins of endemic human coronaviruses (HCoVs) were measured in SARS-CoV-2-infected donors and healthy controls. COVID-19 severity strongly correlated with IgG responses against the nucleocapsid (N) of SARS-CoV-2 and possibly with the number of viral antigens targeted. Furthermore, a strong correlation between COVID-19 severity and serum responses against N of endemic alpha- but not betacoronaviruses was detected. This correlation was neither caused by cross-reactivity of antibodies, nor by a general boosting effect of SARS-CoV-2 infection on pre-existing humoral immunity. These findings raise the prospect of a potential disease progression marker for COVID-19 severity that allows for early stratification of infected individuals.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Coronavirus ; Covid-19 ; Multiplex Serology ; Nucleocapsid Protein ; Sars-cov-2
ISSN (print) / ISBN 1664-3224
e-ISSN 1664-3224
Quellenangaben Band: 13, Heft: , Seiten: , Artikelnummer: 889836 Supplement: ,
Verlag Frontiers
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed