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Lessons from common markers of tumor-initiating cells in solid cancers.
Cell. Mol. Life Sci. 68, 4009-4022 (2011)
Tumor-initiating cells (TICs) have emerged as the driving force of carcinomas, which appear as hierarchically structured. TICs as opposed to the tumor bulk display tumor forming potential, which is linked to a certain degree of self-renewal and differentiation, both major features of stem cells. Markers such as CD44, CD133, CD24, EpCAM, CD166, Lgr5, CD47, and ALDH have been described, which allow for the prospective enrichment of TICs. It is conspicuous that the same markers allow for an enrichment of TICs in various entities and, on the other hand, that different combinations of these markers were independently reported for the same tumor entity. Potential functions of these markers in the regulation of TIC phenotypes remained somewhat neglected although they might give insights in common molecular themes of TICs. The present review discusses major TIC markers with respect to their function and potential contributions to the tumorigenic phenotype of TICs.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Tumor-initiating cells; CD133; CD44; CD47; CD166; EpCAM
ISSN (print) / ISBN
1420-682X
e-ISSN
1420-9071
Zeitschrift
Cellular and Molecular Life Sciences - CMLS
Quellenangaben
Band: 68,
Heft: 24,
Seiten: 4009-4022
Verlag
Birkhäuser
Verlagsort
Basel, Switzerland
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
CCG Molecular Oncology (AGV-KON)