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Kempf, E.* ; Landgraf, K.* ; Vogel, T.* ; Spielau, U.* ; Stein, R. ; Raschpichler, M.* ; Kratzsch, J.* ; Kiess, W.* ; Stanik, J.* ; Körner, A.

Associations of GHR, IGF-1 and IGFBP-3 expression in adipose tissue cells with obesity-related alterations in corresponding circulating levels and adipose tissue function in children.

Adipocyte 11, 630-642 (2022)
Verlagsversion Forschungsdaten DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Components of the growth hormone (GH) axis, such as insulin-like growth factor-1 (IGF-1), IGF-1 binding protein-3 (IGFBP-3), GH receptor (GHR) and GH-binding protein (GHBP), regulate growth and metabolic pathways. Here, we asked if serum levels of these factors are altered with overweight/obesity and if this is related to adipose tissue (AT) expression and/or increased fat mass. Furthermore, we hypothesized that expression of GHR, IGF-1 and IGFBP-3 is associated with AT function. Serum GHBP levels were increased in children with overweight/obesity throughout childhood, while for IGF-1 levels and the IGF-1/IGFBP-3 molar ratio obesity-related elevations were detectable until early puberty. Circulating levels did not correlate with AT expression of these factors, which was decreased with overweight/obesity. Independent from obesity, expression of GHR, IGF-1 and IGFBP-3 was related to AT dysfunction,and increased insulin levels. Serum GHBP was associated with liver fat percentage and transaminase levels. We conclude that obesity-related elevations in serum GHBP and IGF-1 are unlikely to be caused by increased AT mass and elevations in GHBP are more closely related to liver status in children. The diminished AT expression of these factors with childhood obesity may contribute to early AT dysfunction and a deterioration of the metabolic state.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter Adipose Tissue ; Childhood Obesity ; Children ; Ghbp ; Ghr ; Growth Hormone ; Igf-1 ; Igfbp-3 ; Liver Fat ; Obesity
ISSN (print) / ISBN 2162-3945
e-ISSN 2162-397X
Zeitschrift Adipocyte
Quellenangaben Band: 11, Heft: 1, Seiten: 630-642 Artikelnummer: , Supplement: ,
Verlag Landes Bioscience
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Förderungen Bundesministerium für Bildung und Forschung
Deutsche Forschungsgemeinschaft
European Society for Paediatric Endocrinology
Integrated Research and Treatment Center Adiposity Diseases
German Diabetes Association