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Romano, M. ; González Gómez, M.A.* ; Santonicola, P.* ; Aloi, N.* ; Offer, S. ; Pantzke, J. ; Raccosta, S.* ; Longo, V.* ; Surpi, A.* ; Alacqua, S. ; Zampi, G.* ; Dediu, V.A.* ; Michalke, B. ; Zimmermann, R. ; Manno, M.* ; Piñeiro, Y.* ; Colombo, P.* ; Di Schiavi, E.* ; Rivas, J.* ; Bergese, P.* ; Di Bucchianico, S.

Synthesis and characterization of a biocompatible nanoplatform based on silica-embedded SPIONs functionalized with polydopamine.

ACS Biomater. Sci. Eng. 9, 303-317 (2023)
DOI PMC
Superparamagnetic iron oxide nanoparticles (SPIONs) have gained increasing interest in nanomedicine, but most of those that have entered the clinical trials have been withdrawn due to toxicity concerns. Therefore, there is an urgent need to design low-risk and biocompatible SPION formulations. In this work, we present an original safe-by-design nanoplatform made of silica nanoparticles loaded with SPIONs and decorated with polydopamine (SPIONs@SiO2-PDA) and the study of its biocompatibility performance by an ad hoc thorough in vitro to in vivo nanotoxicological methodology. The results indicate that the SPIONs@SiO2-PDA have excellent colloidal stability in serum-supplemented culture media, even after long-term (24 h) exposure, showing no cytotoxic or genotoxic effects in vitro and ex vivo. Physiological responses, evaluated in vivo using Caenorhabditis elegans as the animal model, showed no impact on fertility and embryonic viability, induction of an oxidative stress response, and a mild impact on animal locomotion. These tests indicate that the synergistic combination of the silica matrix and PDA coating we developed effectively protects the SPIONs, providing enhanced colloidal stability and excellent biocompatibility.
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Publikationstyp Artikel: Journalartikel
Dokumenttyp Wissenschaftlicher Artikel
Korrespondenzautor
Schlagwörter C. Elegans ; Spion ; Coating Materials ; Nanotoxicity ; Polydopamine ; Silica; Iron-oxide Nanoparticles; In-vitro; Magnetic Nanoparticles; Cell; Cytotoxicity; Stress; Assay
ISSN (print) / ISBN 2373-9878
e-ISSN 2373-9878
Zeitschrift ACS Biomaterials Science and Engineering
Quellenangaben Band: 9, Heft: 1, Seiten: 303-317 Artikelnummer: , Supplement: ,
Verlag American Chemical Society (ACS)
Verlagsort 1155 16th St, Nw, Washington, Dc 20036 Usa
Nichtpatentliteratur Publikationen
Begutachtungsstatus Peer reviewed
Institut(e) Cooperation Group Comprehensive Molecular Analytics (CMA)
Research Unit BioGeoChemistry and Analytics (BGC)
Förderungen National Research Council
Horizon 2020 Framework Programme