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Open Access Green möglich sobald Postprint bei der ZB eingereicht worden ist.
Reactive oxygen species-scavenging nanosystems in the treatment of diabetic wounds.
Adv. Healthc. Mater. 12:e2300779 (2023)
Diabetic wounds are characterized by drug-resistant bacterial infections, biofilm formation, impaired angiogenesis and perfusion, and oxidative damage to the microenvironment. Given their complex nature, diabetic wounds remain a major challenge in clinical practice. Reactive oxygen species (ROS), which have been shown to trigger hyperinflammation and excessive cellular apoptosis, play a pivotal role in the pathogenesis of diabetic wounds. ROS-scavenging nanosystems have recently emerged as smart and multifunctional nanomedicines with broad synergistic applicability. The documented anti-inflammatory and pro-angiogenic ability of ROS-scavenging treatments predestines these nanosystems as promising options for the treatment of diabetic wounds. Yet, in this context, the therapeutic applicability and efficacy of ROS-scavenging nanosystems remain to be elucidated. Herein, the role of ROS in diabetic wounds is deciphered, and the properties and strengths of nanosystems with ROS-scavenging capacity for the treatment of diabetic wounds are summarized. In addition, the current challenges of such nanosystems and their potential future directions are discussed through a clinical-translational lens.
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Publikationstyp
Artikel: Journalartikel
Dokumenttyp
Review
Schlagwörter
Biomedical Nanosystems ; Diabetic Wounds ; Nanomedicine ; Reactive Oxygen Species ; Treatment Mechanisms; Rheumatoid-arthritis; Cells; Microenvironment; Hydrogel; Exosomes; Ros; Nanoparticles; Angiogenesis; Inflammation; Expression
ISSN (print) / ISBN
2192-2640
e-ISSN
2192-2659
Zeitschrift
Advanced healthcare materials
Quellenangaben
Band: 12,
Heft: 25,
Artikelnummer: e2300779
Verlag
Wiley
Verlagsort
Weinheim
Nichtpatentliteratur
Publikationen
Begutachtungsstatus
Peer reviewed
Institut(e)
Institute of Regenerative Biology and Medicine (IRBM)
Förderungen
European Foundation for the Study of Diabetes